The NFL has cancelled the four games scheduled to take place in London later this year.
Two fixtures involving the Jacksonville Jaguars were scheduled for Wembley, with two more matches due to be played at the Tottenham Hotspur Stadium.
They will now be held in the US after organisers decided it was impossible to arrange games in a different continent because of the coronavirus pandemic.
The London games were set for autumn 2020, but no firm dates had been set.
It will be the first time an NFL regular season game has not been played in London since 2006.